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Foster Delivery Science, a business unit of Foster Corp. (Putnam, CT), has been awarded a Manufacturer's Technical Assistance Program (MTAP) grant from the University of Connecticut for development of processes to improve manufacturability and absorption of poorly water soluble drugs in the body. MTAP is part of an investment by the state of Connecticut in the University Technology Park aimed at supporting manufacturing innovation.

PlasticsToday Staff

March 25, 2013

1 Min Read
Foster, UConn partner to advance extrusion, molding  of pharmaceuticals

 MTAP is part of an investment by the state of Connecticut in the University Technology Park aimed at supporting manufacturing innovation.

According to Foster, many newly discovered pharmaceutical ingredients are poorly water soluble and result in low absorption rates in the body.  Hot melt extrusion technology can enhance bioavailability through melt dispersion of active pharmaceutical ingredients in a polymer matrix.  The resulting drug/polymer matrix is then ground into powder form and pressed into tablets.

Foster and the University of Connecticut will collaborate to develop continuous injection molding of the tablets from the drug/polymer matrix form, eliminating the powder grinding process. In addition Foster and University of Connecticut intend to explore foaming technology to reduce density and increase porosity of the molded tablets in an effort to further enhance the body's absorption of drugs.

"Roughly half of the new drugs discovered are poorly soluble and require special processing, such as hot melt extrusion, for drug delivery dose forms," said Tony Listro, managing director at Foster Delivery Science.  "By combining our expertise in hot melt extrusion and the polymer processing resources at University of Connecticut we believe we can make meaningful advancements in manufacturing and performance of formulations involving poorly water soluble drugs."    

Benefits of hot melt extrusion include:

  • Improved solubility

  • Improved bioavailability

  • Improved dissolution

  • Improved dispersion

  • Controlled release rates

  • Targeted delivery

  • Volume and scale-up flexibility

  • Taste masking

  • Dosage form flexibility

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