K 2013: Drug-releasing absorbable foam

August 22, 2013


Institut für Kunststoffverarbeitung (IKV; Hall 14 C 16) and RWTH Aachen IKV have developed a carrier system for treatment of overactive bladder, which they will discuss at K 2013. The microsphere drug-delivery system (DDS) they devised consists of a drug-loaded polymer matrix that is embedded in a foamed absorbable carrier system. The DDS is directly placed into the urinary bladder, and the drug release is controlled by the degradation of the carrier system. In this way, the active agent has a locally lasting effect in the bladder and won’t affect the whole body as is the case with orally ingested tablets. In addition, a regular use of a catheter in short time intervals several times a day is no longer required.

IKV utilizes the CESP (Controlled Expansion of Saturated Polymers) process to make the DDA. CESP allows temperature-sensitive materials, like the used poly (D,L-lactide-co-glycolide)-co-PEG to be processed. In this case, the material is processed in a high-pressure 50-bar CO2 atmosphere and low 50°C temperatures. CESP allows a powdery polymer microsphere mixture to be foamed specific via a pressure-controlled, continuous, variable discharge. Adjusting the carrier’s degradation to when medication is needed is possible by the termination of the foam structure. For reproducible manufacturing of the carrier system in the range of micrograms, a dosing unit and adapted cavities are integrated into the process chain. IKV believes the CESP process will allows more absorbable, drug-eluting implants applications, including porous osteosynthesis plates or stents.

IKV foam drug delivery system

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