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Wearable insulin-delivery device uses COC polymer from Topas

Valeritas V-Go
Worn like a patch under clothing, the V-Go Wearable Insulin Delivery Device from Valeritas (Bridgewater, NJ) provides an affordable, all-in-one option for patients with Type 2 diabetes. The device will be featured at the Topas Advanced Polymers (Florence, KY) stand at MD&M West in February.

Globally, approximately 425 million adults have diabetes, according to the International Diabetes Federation, which projects that number to rise to more than 550 million people by 2030. It is “one of the most common noncommunicable diseases worldwide,” according to a paper in the International Journal of Pharmaceutical Investigation. That is a huge market, and for many years now, medical device companies have sought to develop more patient-friendly insulin-delivery devices. The insulin pen, first developed by NovoNordisk in 1985, was a huge step forward at the time. The advent of wearable medical technology represents another opportunity to advance insulin delivery, a space where the V-Go Wearable Insulin Delivery Device operates. And, yes, plastics helped to make it possible.

The flagship product of commercial-stage medical device company Valeritas Holdings Inc. (Bridgewater, NJ), the V-Go provides an affordable, all-in-one option for patients with Type 2 diabetes. It is worn like a patch under clothing and can eliminate the need for taking multiple daily shots. The device features an injection molded cartridge made of a cyclic olefin copolymer (COC) from Topas Advanced Polymers (Florence, KY), a business of Polyplastics Co., Ltd. 

After thorough research and evaluation, the Topas COC material was selected over competitive thermoplastics because of its purity, drug compatibility, biocompatibility and dimensional stability, according to Geoffrey Jenkins, Executive Vice President of Manufacturing and Research and Development for Valeritas.

A webinar on effective material selection for wearable device design is now available for free on-demand viewing. Eric Larson, who heads engineering consultancy Art of Mass Production (San Diego, CA), explains how to optimize your materials selection process, a key step in developing a commercially successful wearable product. Watch it now!

“Topas COC fills an important role in the cartridge system of the V-Go insulin delivery device,” said Jenkins. “We find it to be highly stable in contact with the drug and it has great optical clarity; moreover, it offers good injection molding characteristics with excellent dimensional stability and minimal shrinkage.”

Topas COC offers a non-ionic, minimally reactive surface. This non-polar substrate does not promote adsorption, denaturation, aggregation or precipitation, said Topas. The glass-clear resin has very low leachables and extractables compared with glass and other medical-grade polymers for drug delivery. Consequently, it preserves long-term drug purity and enables better quality at high yields, according to Topas.

The tube-shaped cartridge contains 1 ml of insulin. Valeritas reports that users switching from multiple daily insulin shots to V-Go significantly lowered their glucose levels and reduced their insulin use by as much as 44% per day.

Topas will highlight this product and other applications at booth 666 at Medical Design & Manufacturing (MD&M) West. North America’s largest annual medical manufacturing event, MD&M West is co-located with PLASTEC West in Anaheim, CA, on Feb. 6 to 8. Along with thousands of exhibitors, the event also features a comprehensive conference program dedicated to advanced manufacturing. For more information, go to the MD&M website. If you register for any of the conference sessions, be sure to enter promo code PLASTICSTODAY to receive a 20% discount.

TAGS: Materials
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